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Of course, a vast majority of aggregate marijuana sales are still conducted on the black market, giving the industry and investors hope that there's still many years of huge growth that lie ahead. This isn't to say that cannabis reform couldn't be squeezed in, but GOP lawmakers are liable to use a busy docket as an ongoing excuse to keep marijuana reform off the Senate or House floor. With marijuana, there are no guidelines in terms of what represents too much impairment behind the wheel. Now, a new generation of marijuana entrepreneurs has emerged across America. In a handful of pivotal-stage studies, GW Pharmaceuticals' Epidiolex ran circles around the placebo, significantly reducing seizure frequency from baseline, and relative to the placebo, in the process.